This is a summary of the “Tourism in 2040” report, part of the “Greece in 2040” White Paper, an initiative of the “Greece 2021” Committee. The report presents new emerging trends (megatrends) and the impact they will have on tourism, bringing about profound and significant changes in the next decades and inducing the transformation of travel and the tourism product per se. In view of the rapid changes and increased uncertainty, both the modernization and the adaptability of the tourism sector are a great challenge. Greek tourism must regain and improve its position in the global competition setting and at the same time strengthen its ability to address uncertain developments.